Ascorbic Acid Injection Vitamin C and Collagen Vicolla Liquid for Injection

Platinum Laroscorbine 
Vitamin C 10X SKIN WHITENING & LIGHTENING
Collagen ANTI-AGING PRODUCTS 



1. Pharmacology
Ascorbic acid, a water-soluble vitamin, is essential for formation of collagen and intercellular material, 
and therefore necessary for the development of cartilage, bone, teeth and for the healing of wounds. It is also essential for the conversion from folic acid to folinic acid, facilitates iron absorption from the gastro-intestinal tract and influences haemoglobin formation and erythrocyte maturation.

2. Indications
The prevention and treatment of scurvy, or other conditions requiring vitamin C supplementation, where the deficiency is acute or oral administration is difficult.



3. Dosage
Route of Administration: Parenteral

Adults
0.5 to 1g daily for scurvy, 200 to 500mg daily for preventative therapy.

Children
100 to 300mg daily for curative purposes, or 30mg daily for protective treatment.

Elderly
No special dosage requirements have been suggested.


4. Contraindications
Hyperoxaluria
Special Precautions
Ascorbic acid should be given with care to patients with underlying renal due to the risk of formation of renal oxalate calculi. Tolerance may be induced in patients taking high doses.
Large doses of Ascorbic Acid have resulted in haemolysis in patients with glucose -6-phosphate dehydrogenase(G6PD)deficiency.


5. Undesirable effects
Large doses may cause gastrointestinal disorders including diarrhoea. Large doses may also result in hyperoxaluria and renal oxalate calculi may form if the urine becomes acidic. Doses of 600mg or more daily have a diuretic action. Induced tolerance with prolonged use of large doses can result in symptoms of deficiency when intake is reduced to normal.









6. Drug Interactions
Drugs which induce tissue desaturation of ascorbic acid include aspirin,from cigarettes, alcohol, several appetite suppressants, iron phenytoin, some anti-convulsant drugs, the oestrogen component of oral contraceptives and Large doses of ascorbic acid may cause the urine to become acidic Causing unexpected renal tubular reabsorption of acidic drugs, thus producing an exaggerated response.
Conversely basic drugs may exhibit decreased reabsorption resulting in a decreased therapeutic effect. Large doses may reduce the response to oral anticoagulants. It has been reported that concurrent administration of ascorbic acid and fluphenazine has resulted in decreased fluphenazine plasma concentrations.Ascorbic acid is a strong reducing agent and interferes with numerous laboratory
 tests based on oxidation-reduction reactions. Specialised references should be consulted for specific 
information on laboratory test interferences caused by ascorbic acid. Ascorbic acid given in addition to desferrioxamine in patients with iron overload to achieve better iron excretion may worsen iron toxicity, particularly to the heart,early on in the treatment when there is excessive tissue iron. Therefore 
it is recommended that in patients with normal cardiac function ascorbic acid should not be given for the first month after starting desferrioxamine. Ascorbic acid should not be given in conjunction with desferrioxamine in patients with cardiac dysfunction. Aspirin can reduce the absorption of ascorbic acid by approximately a third and decreases urinary excretion by about half. The clinical importance of this is 
uncertain.Patients with kidney failure given aluminium antacids and oral citrate can develop a potentially fatal encephalopathy due to marked rise in blood aluminium levels. There is evidence that vitamin C may interact similarly.Oral contraceptives lower serum levels of ascorbic acid.

7. Presentation
-5 ampoules/tray/box

Marketing Authorisation Holder:
Laboratories Viroche S.A. 
All Designed and formulated from France

Global Supplier and Exporter:
Shandong Sino Pharmaceutical Technology Co.,Ltd.
North of National Road 327, Liuhang Town, High-tech Zone, Jining, China.

Payment: T/T or west union
Delivery time: within 2 working days for ready stocks, 45 working days for batch order.
Shipment: HKEMS,TNT,UPS,door to door service for some countries.

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